People with type 1 diabetes cannot produce enough insulin to regulate blood sugar
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Researchers have 3D printed devices made of insulin -producing cells. These devices can allow a long-term treatment for type 1 diabetes that allows people to produce their insulin-without the need for gaseous surgery.
Since people with type 1 diabetes cannot make enough insulin to regulate blood sugar, they must constantly manage their condition, with injection and food reserves. Long-term treatment includes planting human islands-groups of insulin-producing cells that usually grow in the pancreas-from donors. But like organ transplantation, this requires gas surgery.
“The current practice is the pumping of these human islands through the vein of the gates in the liver,” he says. Queenin Perier At the Wake Forest Institute for Renewal Medicine in North Carolina. However, about half of the cultivated islands quickly lose their function, which means that people should undergo several transplants to make the treatment effectively.
If the carrots can be placed directly under the skin, the surgery will not only be invasive, but it will also produce less stress and inflammation that reduces the functional life of the cells.
“The more intense [of islets]”The size of the device that you will need to plant in the patient,” he says. Adam Venberg At Carnegie Mellon University in Pennsylvania and the Fluidform Bio in Massachusetts.
To achieve this high density, Perrier and its three -dimensional colleagues printed from the “biocones” made of human beanic and committee tissue, a type of carbohydrate derived from seaweed. Cells that produce live insulin are mixed in this substance.
“We put this vital pink with [human] An island in a syringe, and we print a special model [with it]”This porous network is designed to allow the new blood vessels to grow around it and through the structure,” says Pereier.
In the laboratory, this technique “works very well,” says Perier, noting that about 90 percent of the island cells have survived and operated for up to three weeks. “The next challenge is really the validity of this conclusion In the live body.Pererer and his colleagues presented their research at the European Association for Organ Transplantation (ESOT) 2025 in London on June 29.
Feinberg and his colleagues also printed their 3D islands. Their style is to make a working frame by printing cells and collagen directly in the hydrogel polymer – “a type of 3D printing inside the gel of hair,” he says. It was presented at the International Society for Pancreas Agriculture and 2025 Island Islands in Pisa, Italy on June 16. In sugar laboratory mice, the carrot re -controlled natural glucose for up to six months.
Pyrere’s work is certainly “promising”, but the inherent contrast of human tissues used to make the islands can pose challenges in a living body. “It is like getting a transplant member,” he says. “On one side, the material may work better. On the other side, the variable is difficult to obtain, and this is a truly difficult problem to solve it.”
To avoid these transplant problems, both Feinberg and Perrier say that stem cell treatments represent the future of type 1 diabetes treatment. They say that the use of stem cells in the 3D printing process – instead of the cells they currently use – can solve many problems simultaneously.
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