Weight loss pills could help tackle obesity in poorer countries, experts say | Medical research
Experts said that newly developed birth control pills can have a significant impact on obesity treatment and diabetes in low and medium -income countries.
Wegovy and Mountjaro, which contain Semaglutide and Tirzepatide, are popular, are common in countries including UK after experiments have shown that they can help people lose More than 10 % of body weight. Medicines that contain semules and Terzopatid can also be used to help control diabetes.
However, such settings are not cheap, require a pen and needle, and they must remain cooled, which limits their use in low -income countries (LMics).
Experts say new oral drugs that are expected to be cheaper and easier to transport and store can help address increasing health concern in such areas.
“Medicines that can reduce the risk of diabetes and simultaneously reduce the risks of heart disease and other obesity complications can have great benefits in many LMIC as this disease began to rise partially due to the high waist oceans,” said Navid Saturn, a cardiologist at the University of Glasgow.
Dr. Louis Aaron, an expert in obesity medicine at Will Cornell Medical College. “What we will see is that with our progress, patients and health care providers will not wait for people to develop [complications of obesity] When they can prevent them. “
Aaron’s work has shown that when people with obesity and the Terzopatide diabetes were given for three years, the risk of developing diabetes was given It decreased by more than 90 %.
Aaron said: “It is easier to distribute the oral medicine because it will not need a cold chain to ensure infertility and activity like the current injection. It will come in a box or bottle and will not need to be cooled, so it can be used anywhere.”
Among the drugs that cause excitement OrforipronWhich comes as daily pills to control glucose and weight loss. Like semaglutide, OrforiPron mimics a hormone in the body called the GLP-1, which helps people feel hair longer as well as increased insulin production, among other procedures.
According to the pharmaceutical company Eli Lily, 40 weeks 3 Clinical From OrforiPron in people with diabetes found that the drug reduced blood sugar levels and helped patients get rid of pounds. Aaron indicated that he had the effectiveness of weight loss in the Smaglutide range.
Although semaglutide is already available in the form of birth control pills, OrforiPron has more advantages. Satar said that a dose is much higher than the poultry, which was required in the form of birth control pills more than used in JABS to achieve a similar degree of weight loss, and the poultryide should be taken on an empty stomach and should not eat for half an hour after that.
OrforiPron is a small molecule, which means that it is more resistant than the poultry, peptide, to digesting it in the stomach, and therefore it can be eaten alongside food and drink. What is more, is unlikely that OrforiPron requires a high dose of orally, making it cheaper.
Experts say research is continuing to test or for glybrunes for weight loss in people who do not have diabetes and to confirm the safety file – an important step, not the least of which is Pfizer I got rid of Small molecule GLP-1 drug on a possible liver injury caused by drugs.
It is also unclear whether or associated with a reduction in the risk of heart attack, stroke, or death due to cardiovascular disease, as was the case. I found for Smaglutide.
But scientists say that if you reach or similar medications in development to the market, they can help treat obesity and diabetes, including LMics where the spread of these conditions is It rises quickly.
Aaron said: “The best and the best diet is definitely something that can prevent obesity, but once it is established, a better diet will not be treated for most people. Something physically in the brain makes it difficult for people to lose weight and compliance with the diet, which is why the drug seems necessary in this position.”
Such efforts are also important given the relationship between race and obesity diseases. As shown by us and others, Asiis is likely to develop southern blacks – and other ethnic groups – type II by developing type 2 diabetes with lower gains of weight from Eggs of all agesEven small population gains in obesity in many countries will lead to a significant rise in diabetes, adding that there is even there Some trial evidence This drug that mimics GLP-1 may decrease the risk of heart disease with twice as much as Asian people compared to white people.
“The safest and most effective drugs in the market, both by injection, especially orally, to help treat the growing essays, the better the health of many countries,” said Satar.
