The second person has received a transplant with a genetically modified pork.
Tim Andrews, 66, lives in Concorde, New Hampsshire, suffers from kidney disease at the end of the stage and was on dialysis for more than two years to compensate for his failed kidney function. He got the pig’s kidneys at Massachusetts General Hospital on January 25. As part of a new study approved by the American Food and Drug Administration (FDA), which will include a total of three patients.
Andrews was unloaded on February 1 and staying in Boston to continue before returning home. Doctors say that the college is the planted pig works naturally and produces urine.
Hope is that the pork kidneys can help reduce the problem of the membership of the United States according to the transplant team, and Andrews was only a 9 % chance to receive a human college in the next five years, and the opportunity of approximately 50 % to remove it from the awaited awaiting menu due to the deterioration of his health. He left his dialysis to him unable to continue many of his activities usually, and he had a heart attack in 2023. As of last September, almost, almost. 90,000 people were waiting for the collegeAnd in 2023, more than 27,000 transplants were performed-which might treat the gap between demand and supply that rough tankers, or animal to humans can be treated.
How can kidneys pigs work in humans
The challenge with this type of transplant is that the human body often rejects foreign tissues. And Andrews can be the kidneys due to many new genetic developments including cloning and CRISPR, which allowed scientists to modify the organ to make it more compatible with the human immune system. The company, which created the kidneys, eagenesis, removed three main pig proteins on the organ, and has introduced seven human genes to reduce the chances of rejection, and disrupt some viruses in the pig’s genome that would have been harmful to the patient.
this The operation was performed once before. Richard Salaman, who was 62 years old at the time he planted in March 2024, he recovered well, but he died two months later due to reasons that have nothing to do with the college, According to his doctors.
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With Andrews, “it’s the exact same kidneys and the same hereditary [modifications] “Mr. Slayman has received,” says Michael Cortis, CEO of Egenesis. “We have learned enough of Mr. Sliman to say that it looks good enough, and the data is convincing enough that we must try again.”
There is one major change, from the case of Celine. The surgical team, in consultation with the FDA, decided to work on a patient with kidney disease at the end of the stage. While Slayman was in dialysis for eight years and had kidney transplant and heart disease, Andrews was only on dialysis for two years and had the strongest cardiovascular system. This may lead to better results for Android and give doctors more ideas about who is a good candidate for organ transplantation: a person suffers from severe kidney disease, but who is not so sick so that they cannot benefit from the implant.
“Xenotransplant is a turning point by eliminating the deficiency of the organ as a barrier in front of the organ transplant,” Dr. Leonardo Riela, Medical Director of Kidney Transplantation at Massachusetts General Hospital, said at a press conference. “It provides a much higher solution of dialysis.”
Just as Salaman did, Andrews also received an experimental drug called TEGOPRUBART To suppress the immune system for it and increase the chances of not rejecting the pig’s kidneys. It is developed by Eldon Pharmaceuticals, and the drug is studied in many experiments involved in human kidney transplants.
Next Step: Clinical Experiences
Egenesis is not the only company that develops swine organs to plant human. In February, the Food and Drug Administration approved the first major trial of the children of the people, conducted by the UNITED Therapics, which also modifies pig members to make them more compatible with humans. The experiment will eventually include 50 patients, if the first few work well after 12 weeks.
Cortis says that encouraging results from the first patients of pigs, Salaman and Andrews, lead to discussions about the organs of other animals that can be planted, including pig hearts. He says that the results of the chamomile that received the hearts of genetically modified pigs “are” impressive so far. While the company and transplant surroundings initially planned to use the hearts of pigs as a bridge for patients who wait for human hearts-anywhere from 100 to 200 days-the chamoma for more than 500 days. “The results indicate that we may be implanted by the destination and we do not have to go through the bridge,” said Cortis.
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At the present time, the Andrews transplant team will closely monitor its health; Its progress will determine whether and whether the following patients in the experiment receive the kidneys of pigs.
“The first time I saw Tim in the clinic, he was weak and struggled with complications from diabetes,” Rilo said at the press conference. [with a human kidney] He was not certain.
“Tim’s journey is more than one patient’s success,” said Rilo. “It represents the hope for millions with kidney failure, and one step approaches us to make Xenotranslate implantation a widespread solution to the crisis of organ deficiency.”
