WASHINGTON (AP)-Three people suffering from a disease destroyed the estimated muscles to a slightly stronger-able to stand and walk more easily-when a farmer set the spinal cord.
On Wednesday, the researchers reported what they called the first evidence that the transplantation of the spine stimulation A paralysis test is already conducted It may also help in neurological degenerative diseases, such as forklined muscle atrophy – by restoring some muscle functions, at least temporarily.
“These people have not expected improvement,” said Capogrosso, an assistant professor at the University of Pittsburgh, who led the research. However, during a month’s experimental study, “they were improving and better.”
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Disturbance of spinal muscles or SMA is a genetic disease that gradually destroys motor neurons, and neurons in the spinal cord that controls the muscles. This leads to the waste of muscles, especially in the legs, hips, shoulders, and sometimes those involved in breathing and swallowing. There is no treatment. Genetic therapy can save the lives of young children who have a severe form of disease, and there are some medications to slow the exacerbation of older patients.
Spinal cord stimulation has always been used with low levels of electricity to treat chronic pain, but the Capogrosso team has also tested it to help people with paralysis of strokes or Spinal cord injury moves their ends without help. While running, it revolves around circles of sleeping nerves in the direction of the infection course to stimulate the muscles.
Capogrosso then asked whether this technology itself could help SMA in a similar way – by strengthening the related sensory nerves until it wakes up to the damaged muscle cells, which helps them to move to combat wasting.
Pitt researchers planted the electrodes over the lower spinal cord of three adults who suffer from SMA and tested the strength of muscles, fatigue, extent of movement and changes in walking and at the distance of walking when the device was shooting and when it was turned off.
Natural movement was not restored, but with just a few hours of stimulation in the spine per week, all of which have quickly witnessed improvements in muscle strength and functions, researchers said in the Nature Medicine magazine.
“With a progressive disease, it never improves,” said the study participant, Dog McCulo, 57, from Franklin Park, New Jersey. “Either it remains stable or gets worse. So having any improvement is just a very surreal and exciting benefit.”
Capogrosso said that all the three participants increased greatly from the extent of their ability to walk in six minutes, and the person who was not able at the beginning was unable to stand up to the kneeling at the end of the study. The gait of McCallo changed so that each step was three times longer.
“They are less tired so that they can walk for a longer period,” said Kapoguso. “Even a person who can improve this year this year.”
Interestingly, the researchers found that the improvements did not disappear once the catalyst was closed, although they had faded as the participants were followed after the study ended.
“You will just feel the shipment,” said McColeu even when the alarm was stopped.
While he was understood that the device had to be removed at the end of the study, he was disappointed. He said that there are some remaining benefits in examining it for six weeks, but nothing after six months.
The nerves Susan Harkima, who led pioneering studies on stimulation of spinal cord injuries while in Louisville University, treated that the new study is small and short but described as an important evidence of the concept. She said it is logical to test technology against the list of diseases from which muscles are emitted.
“The human pillars are very sophisticated – they are not just a group of brain -controlled reactions,” said Harkima, now with the Kissler Foundation, a rehabilitation institution. “This is a very strong study, and it is an important contribution to move forward.”
In a house, Capogrosso said that some small but longer studies begin.
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