Restoring specific bowel microbes may help treat fertility problems in people with PCOS syndrome
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Women with multi -cyst ovarian syndrome (PCOS) have lower levels of intestinal microbe, which appears to be the risk of complications of pregnancy.
PCOS is The most common hormonal condition In women of childbearing age, it is a major cause of sterility. However, only little is relatively understood about the cause of this or the best way to treat it. For example, it is not clear because of those who have an ovarian cyst syndrome who have pregnancy have a greater risk of complications such as miscarriage, Childbirth prematurely And pregnancy Diabetic.
Axia Leo At Zheyang University in China, her colleagues monitored the results of pregnancy in 220 women in 44 cities in China, half of them were PCOS. All of them were less than 35 years old and gave samples of blood, stool and tissues from the endometrium, or The inner lining of the uterus.
Despite similar pregnancy rates, they were likely to have almost complications from pregnancy complications, such as abortion, premature birth, diabetes, or a child with low birth weight. The researchers also found that those who suffer from PCOS syndrome about half the amount of intestine bacteria are called Pararabacteroi Merdai From those who do not have a condition and this is associated with the results of pregnancy.
P. merdae It helps to convert some nutrients, such as ISoleucine, amino acids, into useful compounds called short -seedily fatty acids that play an important role in reproductive health. Perhaps this explains the reason for the presence of participants in PCOS, on average, about 39 percent of Ezoliosin and 10 percent of levels less than Short sequential fatty acids In blood samples from those who do not have it. They also had higher levels of isoleucine in endometrial tissues.
When the researchers cultivated the endometrium cells to the participants and exposed them to isoliosin in a dish, they saw an increase in the signs of cellular aging, where the cells become eroded or damaged to the point that they stop working. Isoleucine also hindered endometriosis.
“These results indicate age -like changes in the womb,” Liu said in a press release from an annual meeting of the European Association for Human Reproduction and Eagles, as these results were presented. Our data indicates that Ezoliosin levels are high and lost P. merdae The endometrium may weaken, even in women under the age of 35. “
While this indicates that the changes in the intestinal microbium may contribute to fertility problems in PCOS, Andrea Dunif At the Faculty of Medicine in Ikan, Mount Sinai, New York, is skeptical. Her special research indicates that reproductive aging in PCOS is delayed, rather than acceleration. “Its reproductive distortions tend to improve in the 1930s,” says Dunaif. “This makes me skeptical of the importance of the results of the endometrium, and if it is really responsible for these changes and the results of pregnancy.”
However, these results can improve fertility treatments for PCOS. “Microbium is something [where] You can interfere with different probiotics to change [bacteria]”Therefore, it is good to have a potential target for treatment because we are not facing any specific treatments for PCOS,” says Deniev.
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