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There is an increasing set of evidence that is increasingly linked to diet and others Overweight To the extent that the World Health Organization I issued a consultant In May 2023, he said not to use sugar alternatives for weight loss.
“Replacing free sugars with sweeteners other than sugar does not help people control their long -term weight,” He said at that time.
Now, a new study may shed light on the reason for the consumption of many artificial domestic sugar can be inverse results. Instead of the brain sends a signal to eat less, succralose leads to an increase in appetite when consumed in a drink.
“Sugars are activated by the area in the brain that regulates hunger, and this activation, in turn, is linked to greater categories of hunger,” said the main study author at the University of Cake in Southern California in Medicine in Los Angeles.
In fact, people who drank water with succralose said that their appetite increased by almost 20 % compared to drinking water drinking water.
In the United States, SUCRALOSE is a major component in some of the alternatives to Splena Sugar. In Europe, Suclose is known as E955 In sugar alternatives sold under the commercial names Candys, CandERELL Yellow, Cukren, NEVELLA, Splenda, Sucraplus, Sukrana and Zerocal.
The study searched only on the effect of succralose and did not search Aspartameand Acesulfame-k and Sodium.
“This is a very high -quality study, using newer methods and accurate analysis,” said Dr. David Katz, a specialist in preventive medicine and lifestyle. Katz, founder of non -profit organizations A real health initiativeA global alliance for experts allocated to evidence -based lifestyle, not participating in the study.
The authors have carefully interpreted their results, but they provide a strong situation that “the good sweeteners, and Skarlaz specifically, interfere with the organization of natural appetite in ways that can have harmful effects on controlling weight and health.”
A spokesman for the Heartland Food Products group, which is manufactured by Splena, said that local calories are low and usual on thermal letters supported by research recommendations and experts.
“Low or zero health care professionals such as sugar are recommended by specialists in the field of health care, food safety experts, reliable health institutions for diabetes and weight management based on trusted scientific research, which shows that the effect of low or zero localities, reduction, reduces localities, reduces broadcasting pants, reduces the volume of corners on the record, reduces management from the records Al -Saqafi, the reduction of management from the converging records, the management of the administration from the authentic records, the management of the administration, and the management of the administration from the ceasefire obligations.
The results of the study support previous research
The idea that artificial sweeteners may increase hunger signals from the mammal brain are not new – a Previous study Participate in composing the page that found that women and people with obesity were especially sensitive.
“Studies on animals have alluded to some of these effects,” Katz said. However, “this, as far as I know, the most decisive study in humans with direct effects on the center of appetite.”
All cells in the body require glucose for energy. The brain is the largest user, adheres to it Half of all sugars Blood trading. However, the nature of the brain is designed to respond to natural sugars such as glucose found in whole fruits and some vegetables.
Big said that artificial sweeteners seem to mix the brain, by sending sweets signals without providing the required calories required by the brain. Scientists have assumed that when these promised calories do not reach, the brain may send a signal to eat more.
The same people, three drinks
The new study, It was published on Wednesday In Nature Metabolism, 75 people were asked to consume one of three drinks on three separate occasions: regular water, sweetened water with table sugar (scrub), and sweetened water with scrubs.
During each visit, the research team tested blood sugar levels for the participants, followed by a brain examination called functional magnetic resonance imaging, or functional magnetic resonance, which tracks blood flow to capture activity in different areas of the brain.
“They got out of the scanner, consumed one of the three drinks, and returned to the scanner,” said Beige.
Big said that one cup contains 300 milliliters of water and 75 grams (about 2.5 ounces) of sugar (sugar), which is equivalent to a box of 16 ounces of sugary soda.
There was another drink of enough sugar to match that sweetness. Sucralose about The best 600 times sugarAccording to the American Food and Drug Administration. The third drink was the ordinary water, which was controlled.
While wiping the brain, Page and her team collected another round of blood samples in 10 minutes, 35 minutes and 120 minutes of drinking the drink and asked the participants to assess the level of hunger.
“(The study) is particularly strong because it used repeated measures within the same participants and included different ways such as brain imaging, blood withdrawal, and self -classification to test their hypothesis,” said Kyle Burger, a scientist at the Monel Chemical Center in Philadelphia, who searches in the human senses from the human senses The smell and smell. Burger did not participate in the study.
Three possible explanations
In addition to finding that drinks with SUCRALOSE increased the feeling of hunger by about 17 %, I found page and its team increasing contacts with other parts of the brain responsible for controlling the motivation.
“SUCRALOSE seems to affect your decision -making skills,” said Beige. “For example, we found an increase in brain connection between the hypothalamus and the anterior belt cortex, which controls the risks and rewards of decision.”
In addition, blood tests have shown that sugar had no effect on the hormones that the brain uses to see when we are satisfied and we are no longer hungry.
“There is no indication, no signal at all,” she said. “There is a sweet signal, but there is no hormone signal that tells you that you are full. Suclose does not have an effect on these hormones.”
Katz said that everyone may feel the common effects of sugar in the same way.
He said: “Those who suffer from insulin resistance, for example, may be especially vulnerable to disrupting normal appetite control with sugar.”
What to do?
Big said that the recommendations on how to manage body reactions to artificial sweeteners are currently complicated. For example, the American Diabetes Association tells people with insulin resistance and diabetes Use drinks and foods without caloriesBut little.
“I am an endocrinologist, so I see diabetics and obesity,” said Beige. “I will never say a drink or eat more sugar.
She said: “Instead, I told my patients not to rely on non -emotional sweeteners as an alternative to sugar and try to limit the intake of foodstuffs in general.”
Katz agreed, preferring to suggest a form The taste of “rehabilitation” bud “rehabilitationThis can reduce the general use of sugars, regardless of their shape.
Katz said: “A really healthy diet has a little sugar added in the first place, and therefore there is no sugar to replace it with sugar compounds and relevant vehicles.”
He said that just as many people cut their use of salt, it is possible to cut your use of sweeteners by teaching taste buds for less sweets. The taste buds will respond by finding sugary foods that were now delicious, or in the case of sodium, a lot of saline, The research has shown.
Start by finding hidden sources of sugar in foods that may not be aware of it, Katz told CNN in a previous interview.
“If you ask you to boycott all sweets in your life, you are likely to rebel or fail,” Katz said. “But there is a huge amount of additive sugar and sweeteners hidden in non -sweet foods – in salad sauce, pasta sauce, bread, crackers, even salty chips.”
He said that by choosing products without sweetening, it is possible to reduce the daily intake of diabetes or sweeteners “by a third, and perhaps even half of fines a day before we put his hand on anything you already expect to be sweet.”
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