A clarification of the treatment of T -cell cells that target multiple myeloma, a type of leukemia
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The TD treatment of the car has the ability to revolutionize how we deal with certain types of cancer Through the genetic engineering of the person’s immune cells to attack the disease – but they are also exhausting and expensive. Now, scientists have been able to create a detailed treatment within the body of non -human animals, which may simplify the process, which leads to a decrease in costs.
Treatment is mainly available in countries including the United Kingdom and the United States for some people who suffer from different types of leukemia, including some types of leukemia, where cell B, part of The immune systemIt grows in an irreplaceable way. In these cases, the collection of a sample of immune cells called the T cells of the patient’s blood and genetic genetic engineering inside these cells to target the cell B and kill them permanently. Then these engineering cells are hit and overwhelmed in the body.
But this process takes some time. “You have to take blood, ship it to a central manufacturing laboratory, then return [the T-cells]He says Karl June At the University of Pennsylvania. “This means it is very difficult to expand.” It can also cost More than $ 500,000 For every patient.
To develop a more efficient approach, June and his colleagues turned into genetic molecules, in this case RNA DNA,, Which carried instructions to make a protein that recognizes the cell B. They mobilized these molecules in fatty capsules, which were coated with a protein that allowed them to enter the T cells, which then acquire the ability to identify and destroy cell B. This effect is only temporary, as the RNA remains in T -cells for about a week before decomposition.
Putting their approach to the test, the researchers drowned the BC cells and T-Cells In mice raised to lack the immune system. After one week, they injected animals with five doses of sebaceous capsules for about two weeks, with some mice receive higher doses than others.
Three weeks later, mice that received the highest dose of any detected tumor cells and did not have any side effects. “The levels of tumor cells were close to the extent that we can discover them to eliminate them,” says June.
The team also achieved fatty capsules in 22 healthy monkeys. These T -cells created in the body that have completely cleared all B cells in just one day, indicating that the approach can treat this type of leukemia in the main. The B cells, which make antibodies, are an important part of the immune system, yet the treatment was well tolerated in all monkeys except for one, which had a sharp reaction.
“This is really impressive,” he says. Karen Strethov At the University of London. She says this is a simpler procedure to make cell therapy, which may make it more affordable.
Straathof says that one of the benefits of T -cells for traditional cars is that it can provide long -term protection. The new approach is not temporarily caused by such cells, so more injection will be needed if cancer returns. Also, we cannot be sure of the effectiveness or safety of the latest way in people who do not have clinical experiences, she says.
Jun says the team is already testing the approach in healthy humans. “The first person has been dominated in the past few weeks,” he says.
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