The study indicates that lowering bad cholesterol levels may reduce the risk of dementia by 26 %.
People who have low levels of low-density lipid-c sebuminous cholesterol (LDL-C) in their blood have a total risk of less dementia, and a low risk of Alzheimer’s disease specifically, specifically, According to the published research In the journal Neurosurgery for Neurosurgery and Psychological.
The researchers found that taking statin also provided an “additional protective effect” against the condition of these people with low levels of bad cholesterol.
It is expected that the number of people living with dementia around the world will reach approximately three times 153 million by 2050But the evidence indicates that nearly half of the cases can be prevented or delayed.
LDL-C is often referred to as bad cholesterol and can cause plaque in the arteries, which leads to cardiovascular disease, which may increase the risk of strokes, heart attacks and death. However, until recently, the relationship between LDL-C levels and dementia were less clear.
Last year, Lancet report was found 7 % of dementia has been associated with high levels of middle -aged cholesterol. A new study now indicates that the presence of low levels of LDL-C can reduce the risk of dementia by a quarter of.
Researchers collected data On 571,000 people in South Korea, they have not been diagnosed with dementia -192,213 people with LDL-C levels less than 1.8 mmol/L and 379,006 patients with LDL-C levels above 3.4 mm/l (> 130 mg/dL).
The subsequent diagnostic analysis of dementia showed that the LDL-C levels are less than 1.8 mmol/L. linked to a decrease of 26 % at the risk of dementia and 28 % reduced at the risk of Alzheimer’s disease specifically, compared to LDL-C levels above 3.4 mmol/L.
Statin seems to provide additional protection against dementia in the presence of low levels of LDL-C. Among the people with LDL-C levels less than 1.8 mmol/L, the use of statin has been linked with a 13 % decrease in the risk of dementia and 12 % reduced at the risk of Alzheimer’s disease, compared to non-users.
This was a observation based study, and no fixed conclusions can be extracted on cause and influence. The authors have also admitted several restrictions, including focusing on the basic LDL-C levels when fat features can change over time.
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However, they concluded that “low LDL-C levels … are significantly linked to a decrease in the risk of dementia, including dementia associated with Alzheimer’s disease, with statin treatment provides additional preventive effects.”
“It is clear that there is a story of Alzheimer’s disease more than we believed first,” said Dr. Francesco Tamanini, a neurological physiology at the University of Reeding, who did not participate in the study.
“This paper is looking at the possible causal relationship between high levels of bad cholesterol and dementia. The results give a convincing argument for researchers to consider LDL cholesterol as well as classic methods.”
“It seems that the use of statin provides a protective effect – even for those who already have cholesterol levels in a lower range,” said Dr. Julia Dodley, head of research at Alzheimer’s Research UK.
“However, the risk of dementia is complex and is affected by many factors. Without a detailed image of what is going on in the brain, we do not know whether there is a direct link between the decrease in cholesterol in cholesterol and reduce the risk of dementia.
“Clinical trials will be a key to understanding the effects that statin may have on the disease processes in the brain.”
