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Scientists develop injection for long-lasting contraceptive implant | Contraception and family planning

The researchers develop an injection that creates the cultivation of contraceptives in the body using an approach that can preach a new way in delivering drugs over the past periods of time.

Cultivation of current contraceptives lasts for years, which means that women do not have to take birth control pills every day, but devices must be installed by a trained professional through a small surgical procedure. Contraceptive injection is already available but has restrictions, including it lasts for only three months.

Scientists now say they have completed the experiences of proving the concept of a new type of long -term transplant that lasts in the body.

Although it has not yet been tested in humans, researchers behind the work say the approach can bring benefits beyond the field of birth control, which provides a simple way to manage long-acting drug delivery systems without the need for invasive procedures-attractive possibility of parts of the world with bad medical infrastructure.

“It is suitable for any insoluble soluble drug, especially in the case of a long -acting birth. This includes treatments for HIV, tuberculosis, schizophrenia, chronic pain, or metabolic disease,” said Dr. Giovanni, a participating matter in the Massachusetts Institute of Technology and the Mispnny scientists.

This approach includes injecting the exact crystals of the artificial version of the progesterone hormone in a solvent that does not mix well with water.

Once in the body, exchange of solvents with physical fluid. However, small crystals prefer assembly together than interacting with this water -rich environment. This, in addition to the formation of other crystals with the exchange of solvents, leads to the development of a solid transplant, capable of releasing the drug slowly over time.

The team that published its studies In Nature Chemical EngineeringTest the approach in mice, allowing them to improve the selection of the solvent in the injection. The release of the drug in mice was at least 97 days, although Traveso said there was a possibility for longer periods depending on the formula adjustments.

He said: “The doses and sizes of the drug are compatible with multi -year doses,” adding that the formation of solid transplantation means that it can be removed if necessary, while the approach is also compatible with the use of small needles.

However, the research is still in its early stages, with the effectiveness of the approach that has been tested yet. “It sets the basis for future human studies that we hope will start in the three years to the next five,” Travorso said.

Dr. Janet Parter, head of the sexual and reproductive health care college, said the approach could be an exciting progress.

“This innovation has the ability to be a suitable option for individuals in low resource settings, as access to contraceptives and health care can be limited,” she said. “We welcome more safety, effective and easy access to this promising technology and encourage authors to work with potential future users to ensure meet the needs and preferences of those who depend on them.”

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