Fibry cells, which contribute to the formation of connective tissues but also participate in the scars
Dr. Torrestin Whitman/Science Photo Library
A new insight into how oral wounds heal without scars can pave the way for treatments that prevent permanent impurities or distortion leather.
“There are millions of people with scars of many things – injuries, surgeries and burns,” he says. Over Klein At Cedars-Sinai Medical Center in Los Angeles, California. “It is a huge burden not only in terms of cosmetics, but in terms of function.” For example, a large scars may be tightened on your leg, while impeding movement.
To address this, Klein and his colleagues have taken advantage of the fact that the wounds inside the mouth heal without scarring. He says: “If you bite the inner part of your mouth, not only heal more quickly than the skin, but it cures better in terms of the absence of a scar.”
Given the reason for this is the case, the researchers created wounds at the level of 2.5 millimeters inside the mouths and on the faces of the mice. Then they collected tissue samples from wounds while they were recovered during the following week.
The team examined the participating cells in scars called fibrous cells, and it was found that those in the mouth had a larger activity in the genes that cod the proteins called Gas6 and AXL compared to the fibrous cells in the skin. It is known that these two proteins interact with them Enhancing cell growth, immigration and survival survival.
The GAS6-AXL path appears to suppress the protein levels called FAK, which deposits proteins in wounds to form scars. We knew that the path was present, but we did not know that he was involved in healing the beating wounds, says Klein.
After that, the researchers asked whether the enhancement of the GAS6-AXL path could reduce the scarring of the skin, so they applied a solution that contains Gas6 to the newly formed face wounds. After two weeks, these wounds had lower levels than FAK and the lowest delegation compared to the corresponding wounds in the uneducated mice. “They have proven well that strengthening this path can reduce scars,” he says. Jason Wong At the University of Manchester, UK.
“It is definitely a starting stone for what could be a world -free world,” he says. Ines Sequeira At Queen Mary University, London. But there are differences between mice skin and people, so additional work must test the approach in large animals such as pigs, which have a large -like skin, before conducting human experiments, she says.
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