This propaganda article is presented to you by College of Engineering at New York University Tandon.
In great progress in the field of drug delivery, the researchers have developed a new technology that deals with a constant challenge: developmental manufacturing for nanoparticles and fine particles. This innovation is led
Natalie M. PinkerThe assistant professor of biochemical and molecular engineering at the Tandon College of Engineering at New York University, by blocking the gap between laboratory delivery and drug manufacturing research on a large scale.
This achievement, known as SNAP, depends on current nanoparticles to provide improved and expandable control, which are basic factors to ensure that medicine connecting techniques reach patients efficiently and effectively. This technique enables scientists to
Manufacture of carcass molecules that maintain their structural and chemical safety, from laboratory settings to mass production– A basic step towards bringing new treatments to the market.
Using 3D printing to overcome the challenge in delivering medications
The nanoparticles and fine particles carry a tremendous promise to connect the targeted medications, allowing the transmission of medications accurately directly to the disease sites while reducing the side effects. However, the production of these particles constantly widely was a major obstacle to translating promising research into applicable treatments. As Penkerton explains, “One of the biggest obstacles that prevents the translation of many of these micro -medications is manufacturing. With Snap, we deal with this challenge directly.
Penkerton is an assistant professor of molecular chemical and biological engineering at New York University Tandon.College of Engineering at New York University Tandon
Traditional methods such as nanoparticles (FNP) have succeeded in creating some types of nanoparticles, but they are often struggled to produce larger molecules, which are necessary for some delivery methods such as delivery by inhalation. FNP creates a basic peeling polymers particles (NPS), ranging from 50 to 400 nm. The process includes mixing the particles of the drug and shared polymers (special molecules that help in the formation of molecules) in a solvent, which is then mixed quickly with water using special mixers. These mixers create small controlled environments where particles can form quickly and evenly.
Despite its success, the FNP has some restrictions: it cannot create stable particles greater than 400 nm, the maximum drug content is about 70 percent, production is low, and it can only work with water -hated molecules (waterproof). These problems arise because the formation of the heart of the particles and the stabilization of the particles occurs simultaneously in the FNP. The new Snap process overcomes these restrictions by separating the steps of basic confirmation and installation.
In the Snap process, there are two steps to mix. First, the basic ingredients are mixed with water to start forming the heart of the particles. Then an installation factor is added to stop the growth of the nucleus and fix the molecules. This second step must take place quickly, less than a few parts of a second after the first step, to control the size of the particles and prevent assembly. Current Snap settings connect specialized mixers, respectively, to control the time of delay between steps. However, these devices face challenges, including high costs and difficulties in achieving short delay times needed to form small particles.
The new approach that uses 3D printing has resolved many of these challenges. Progress in 3D printing technology now allows the creation of accurate and narrow channels required for these mixers. The new design eliminates the need for exterior tubes between the steps, allowing shorter delay times and preventing leaks. The innovative mixer design combines two mixers in one setting, making the process more efficient and easy to use.
“One of the biggest obstacles that prevents the translation of many of these fine drugs is manufacturing. With Snap, we deal with this challenge directly.
Natalie M Penkerton, New York University Tandon
Using this new Snap blender design, researchers have succeeded in creating a wide range of nanoparticles and micro particles loaded with the Robrin (fluorescent dye) and scenarios (a weak -walled water medicine used to treat nausea and vomiting). This is the first time that small nanoparticles are manufactured less than 200 nm and accurate particles using Snap. The new setting also showed the decisive importance of the delay time between two steps mixing in controlling the size of the particles. This control time allows researchers to reach a larger range of particle sizes. In addition, successful packaging was achieved for each of the weak water and weak water in the nanoparticles and fine particles using Snap for the first time by the Pinkerstone team.
Democratic characteristics access to advanced technologies
The Snap process is not only innovative, but also provides a unique practical application that gives a democratic character access to this technology. “We share the design of our mixers, and we prove that it can be manufactured with 3D printing,” says Penkerturton. “This approach allows academic laboratories and even industrial players on a small scale to try these technologies without investing in expensive equipment.”
Makkas mixer scheme, with an insertion stage for syringe connections (higher), which is directly connected to the first (middle) mixing stage. The first mixing phase is switched, either with a mixer option with two entrances or four entrances depending on the desired particle size system (anti -dissolving streams for dotted only in a mixer with 4 entrances). This stage also contains a pass of the flows used in the second mixing step. All flows are mixed in the second mixing stage (bottom) and get out of the device.
Snap technology access can accelerate progress in the field of medication delivery, and enable more researchers and companies to use nanoparticles and fine particles to develop new treatments.
The Snap project represents a successful multidisciplinary effort. Benkertun highlighted the diversity of the team that includes experts in mechanical engineering and operation engineering in addition to chemical engineering. She pointed out that “it was truly a multidisciplinary project,” noting that the contributions of all team members – starting from university students and to post PhD researchers – had an effective role in bringing technology to life.
Beyond this achievement, Benkeron imagines that Snap is part of its broader mission to develop global drug delivery systems, which can ultimately lead to the transformation of health care by allowing the delivery of various and developed and customized drugs.
From industry to academic circles: a passion for innovation
Before arriving at New York University, Benkeron spent three years in the Fayzar Oncology Research Unit, where new nanoparticles were developed to treat solid tumors. She says the experience was invaluable. She notes that “working in the industry gives you a realistic perspective about what is possible.” “The goal is to conduct a translation research, which means” translates “from the laboratory table to the patient’s bed.”
Penkerton – who obtained a Bachelor’s degree in Chemical Engineering from the Massachusetts Institute of Technology (2008) and a doctorate degree in chemical and biological engineering from the University of Princeton – was attracted to New York Tandon University, partly because of the opportunity to cooperate with researchers around the world. New York University’s ecosystem, which you hope to develop new nanoparticles that can be used to connect control and other vital applications.
It also came to the academic circles because of the love of teaching. At Pfizer, she realized its desire to direct students and follow innovative and multidisciplinary research. “Students here want to become engineers; She said, “They want to make a change in the world.”
Its team at PinkerTon Research Group focuses on developing fast -responding soft materials to vital applications from the delivery of controlled drugs to vaccines and medical imaging. By following a multidisciplinary approach, they use tools of chemical engineering and material engineering, Nano technologyChemistry and biology to create soft materials through developable structural processes. They focus on understanding how the process teachers control the characteristics of the final matter, and therefore how the material behaves in biological systems – the final goal is to create a global platform for delivering medicines that improve health results through diseases and disorders.
Its Snap technology is a promising new trend in seeking to expand the scope of drug delivery solutions effectively. By controlling assembly with one millimeter accuracy, this method opens the door for the creation of increasingly complex molecular structures, providing a developmental approach to future medical progress.
As for the field of medication delivery, the future is bright as Snap paves the way for a more easy, adaptive and developmental solutions.
