Blood test suggests preeclampsia risk using RNA

Pregnancy poisoning can lead to many complications of pregnancy, including death, but it may be difficult to discover Early pregnancy. The new blood test can help doctors determine those at risk of developing the condition months before the symptoms start.

“We can narrow it to about 1 out of every 4 cases of pregnancy that is truly of great danger, and this is a big step,” he says. Manish Jain In Murphy, a California -based health company.

Pregnancy is a type of hypertension in pregnancy (HDP) that occurs when there is something – scientists are not specifically sure – specifically walking during the development of the placenta. This leads to high blood pressure, which can cause cardiovascular disease, organ damage, seizures and even death. It can also harm the developing fetus.

It may be difficult to hunt pregnancy poisoning and other HDPS, because symptoms usually appear until at least 20 weeks after pregnancy. Sometimes, the signs are not discovered. and Monitor the development of the placenta It is difficult to take a sample of the tissue from the member very invasive.

The new blood test is relatively non -surgical, and the RNA signs are used to predict whether someone is likely to develop HDP. Specifically, the test focuses on certain genes, including Pappa2 and CD163The previously linked expression has been linked to HDPS. The researchers wanted to know if they could discover this excessive expression in blood samples.

The study of checking the health of more than 9,000 pregnant people indicates that they can: Jin says that the test was able to determine more than 99 percent of the accuracy whether someone without risk factors in advance had exceeded genes, and thus was at risk of a pre -erythrocyte race or otherwise. Almost a quarter of the participants without the presence of HDP risk factors in the expression of genes.

It is known that people in the population composition-for example, those who suffer from pre-existing blood pressure or a family history of preeclampsia-have a greater risk than the moderate to develop the condition, he says Morten Rasmussen In Murphy. But for many, it apparently comes out of blue.

Once someone knows that he is at risk of preeclampsia, he can take measures to prevent this. Common interventions include taking medications such as aspirin, and converting to a Following a Mediterranean diet And monitoring blood pressure daily.

However, only the new test looked at people between the ages of 17.5 weeks and 22 weeks in pregnancy. “From an ideal point of view, aspirin should start 16 weeks ago,” he says. Catherine Gray At the University of Washington, Seattle. “So we have already lost that window by the time when most people will get the results of this test.”

Murphy plans to provide a commercial blood test soon. Once it is on the market, the team hopes that other scientists will use it to develop medicines that specifically target genes like genes Pappa2. Such as this molecular appointment “gives a much better chance of treatment to show the effect.”

Gray also would like to see researchers using MirVie’s Bank of RNA to increase genes behind the risk of pregnancy poisoning of certain people. She says the narrowing of the search profile can help reduce the cost of the test, which makes it accessible to more people.