Protected mice for treatment against common tipan, as well as other snake types
Matthijs Kuijpers/Alamy
Anti -snake on the basis Antibodies Among the immune immune man seems to be effective against multiple bites, which increases the possibility of global treatment at hand.
Snake bites cause up to 137,000 deaths per year About three times the number of amputations and disability. Anti -anti -snakes are currently being created using the antibodies from sheep or horses that have been tagged.
But pumping non -human antibodies can cause severe side effects, such as life -threatening allergic reactions. This also means that the snake responsible for a bite must be determined before the antibiotic delivery.
Jacob Glinfille At Centivax in the field of biotechnology in San Francisco, California, his colleagues are looking for widespread antibodies that can be developed into an anti -anti -many or even, or even, or even, Snakes. “Although there are 650 species of toxic snakes, all of them use the same 10 general groups of toxins,” says Glenville.
The researchers first sought to get a bitten person several times through different snakes. “Maybe he was a clinical snake,” says Glangle. Then he heard media reports on Tim FaridAnd that, according to his biography online, “gathered” more than 700 dedication doses of snakes from the most snake in the world.
“If anyone could generate antibodies widely against snow poison, it would have been a Freddy Tim,” says Glansel.
From 40 milliliters of Freddy blood, around the team “its immune memory to a library of billions of antibodies,” he says. Then promising candidates were tested on mice that were subjected to poison from 19 from the World Health Organization list of the most dangerous types of the Elapidae family, including many cobra Class.
Ultimately, antibodies were transformed from Freded blood, called LNX-D09 and SNX-B03, along with a toxin inhibitor called Varespladib, in treatment. When this was tested on mice, complete protection against 13 species, including several types of cobra, tiger snake (Netchis Scotaus) And common taipan (Oxyuranus Scutellatus). It also provided partial protection against the remaining six species, including the common death snake (Acanthophis Antarcticos).
The next step is to test the treatment on animals that are brought to veterinary clinics in Australia after the snake bite, and to find antibodies that give coverage against snakes.
Tian de At the University of Sydney, Australia, she says that “finding only counter -bodies (with inhibitors) can cover such a spectrum of snakes that gives hope in global treatment in the near future.”
But Du, who found that the Nakula Medicine Hebarin can prevent people who lose the limbs after Cobra bitesHe wants to know if the team therapy can prevent skin necrosis and muscles.
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