Explanation of expanded ovary in a person with multiple ovarian syndrome
Scientific photo library/Islam
Multi -cysty ovarian syndrome may be passed through families through chemical signs that change the structure of the DNA, indicating that medications that adjust these signs in fetuses can prevent the condition.
In people with multi-cyst ovarian syndrome (PCOS) at least two of three main features: high levels of male sexual hormones such as testosterone, irregular periods or nothing at all, and the accumulation of immature eggs-which appear such as cysts-on the ovaries.
The situation is often running in families, but it is not exactly clear how it is inherited. “About 25 to 30 [genetic mutations] “PCOS has been linked, but this explains a small part of the inheritance,” he says. Elisabet Stener-VICTORIN At the Carolinska Institute in Sweden.
Studies in mice indicate that the changes are in Lagine signs – Chemical signs that operate genes and stop them without changing the DNA sequence – may also play a role. Most of these signs are believed to be erased when eggs are formed, but some are believed to remain, which is a possible form of inheritance.
To find out if this happens in relation to PCOS in humans,, Chianchu Chu At Chungzheng Medical University in China and his colleagues, his colleagues analyzed the signs of Lagine in eggs and fetuses, which are 3 days old, donated by 133 people with PCOS and 95 without condition. “No one really did this in this way in human materials,” says Stanner Victorian.
This revealed a link between being a donor to PCOS and changes in the patterns of three types of ligament in eggs and fetuses. Two of these signs are transmitted by genes by making DNA rolls more compromised about the proteins called Heston, which help be packaged inside the cells. This makes the genetic code in the DNA less accessible to the molecules that it copies to the RNA, which is a basic step in making proteins. The third type of mark activates genes by relieving DNA rolls.
Together, the Lagine changes associated with integration with egg metabolism and fetuses changed, indicating that they may raise the risk of ovarian cyst syndrome. But more studies must be explored how to affect the symptoms of PCOS at the offspring of mice and humans, says Stanner Victorin. “At the present time, we only know that these signs are different; they do not necessarily mean that they have a negative effect,” she says.
In another experiment, the team used a drug to reflect Laginical changes, indicating that this may reduce the risk of PCOS. “If we confirm that changing these Histon signs change the features of PCOS in the next generation, we have a strong goal of prevention,” Zhu said in a press statement. And more than that, the team says doctors can use the Lagine signs of PCOS to choose the most healthy embryos during fertilization in the laboratory.
ZHU presents the results at the annual meeting of the European Association for Human Reproduction and Furnis in Paris on July 1.
Topics:
