High blood pressure is a common symptom for the east predecessor
Natalia Petrovic/Allama
Early delivery of children, when it is possible, is the only way to deal with the subscriber Load Complications before breaking. But the condition has now been successfully treated in mice by connecting flexible molecules to the placenta to enhance the growth of new blood vessels.
The next step is to test this treatment in large animals, such as Guinea pigs and non -human monkeys, he says Kelsey swingle At the University of Pennsylvania. “This is something that we talked about in the right term really.”
If the treatment proves its effectiveness in large animals, the team begins to test it first in people who develop early before pregnancy.
“If you get pregnancy poisoning in the eighth or nine month of pregnancy, you will stimulate early, but this is not an option if you have severe pregnancy poisoning in the fourth or fifth month of pregnancy. A team member says:” It is very likely that you will lose the child. ” Michael MitchellAlso at the University of Pennsylvania. “This is where the treatment can [address] Immediate need. “
It can also be used later in pregnancy to avoid the need to urge birth early, which can affect health From infants.
About 1 out of 25 women develop before pregnancy during their first pregnancy, which may lead to dangerous Consequences. Globally, poisoning requirements are estimated at 75,000 women 500,000 infants every year.
Red poisoning is usually diagnosed on the basis High blood pressure After the twentieth week of pregnancy, along with signs of kidney damage, such as proteins in the urine. Swingle says: The reason behind this is the failure of the arteries that connect the uterus to the placenta to develop completely as usual.
Therefore, in theory, enhancing the growth of the artery in the placenta can be treated in advance. We know that a protein called Vegf is promoting the growth of blood vessels – the issue reaches the placenta.
If proteins such as VEGF are injected into the blood, they will be cleared quickly, says Swingle. This can be overcome by providing recipes to make proteins instead, in the form of flexible molecules covered in a fatty substance to form nano -fat particles (LNPS).
When LNPs are eaten by cells, the meal of the cells tell the cell how to make the required protein. The molecules are divided after a period of time, so the effect is temporary.
thus Covid-19 Frank vaccines are working, so the approach was already tested in pregnancy, says Swingle. “Many pregnant women have been vaccinated against Covid-19.”
LNPs used in Mrna Covid-19 vaccines are taken by muscle cells because they are injected directly in them. But if LNPs itself is injected into bloodIt is eaten almost all with liver cells.
So the big challenge of Swingle and her team found a way to get LNPs to the placenta. To achieve this, they created and tested a hundred or so LNPs with slightly different chemical properties.
When I use the most promising team of this LNPs to deliver flexible molecules for VEGF coding to pregnant mice with preeclampsia, the pressure of mice blood has returned to normal for the rest of the load.
He says: “This approach deserves more study in the highest -ranking princesses, and if the animal data means safety and effectiveness, in women with prior presentation,” he says. Peter von Dadelsen At King’s College London.
Studies conducted on mice that use flexible coding of fluorescent protein show that LNPs is taken by the spleen and somewhat by the liver, as well as the placenta, a potential safety problem. Most importantly, though, there was no sign of the LNPS placenta crossing mice in fetuses.
Although there is no current treatment for ways, the risks are particularly large without advanced medical care. Mitchell says: “Incaling therapy that does not require all this complex standard for expensive care can be transforming into the development of global applications,” Mitchell says.
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