New type of brain cell may tell us when to stop eating

Nerve cells tell them the brains of mice by stopping eating when they have enough food – and since people may have the same cells, we may manipulate them one day to help obesity.

He says: “The main question we were seeking to answer is how the brain senses and responds to different signals,” he says. Alexander Nakto At the University of Colombia, New York.

To find out more, he and his colleagues used a kind of molecular stereotype to distinguish between a different cell Types of mice brains. In the RAPHE nucleus – part of the function associated with function including eating, mood and sleep – they encountered cells that produce a hormone called Cholecystokinin, which helps to regulate appetite.

To study what these cells feel for kicking at work, researchers measured their activity because the mice were in their day. “Every time the animals go a bite of food, the activity rose and then decomposes,” says Naku. “We are able to show that these neurons feel things like a smell and scene of food, food taste, food sensation in the intestine and nerve hormones that are released in response to food in the intestine, and take advantage of this information to finish a meal in reality.”

After that, the researchers used a technique called optics, which includes neuronal engineering so that they can be turned on and stopped with light. When they used the light to activate it, the eating mice slowed. The more the activation process, the faster the animals slow down and then stop.

Since nerve cells sit in the brain stem, which is the advantage of the ancestors similar to vertebrates, Nextow believes that we are most likely to us. “Although we did not confirm this, my glowing will be that humans have these neurons, definitely.”

The team also found that mouse nerve cells can be activated by a compound called the Betty -1 (GLP -1), which is a type of drug used to treat obesity and type 2 DiabeticThe most knowledgeable is semaglutide, which is sold under commercial names like OzemPIC and Wegovy.

If these neurons have the same function in people, we can theory to adjust them to control eating habits in those who suffer from obesity or even combine this approach with the medicines based on GLP-1, to achieve greater Weight lossHe says Naku.

He says: “Understanding the circuits that govern the cessation of eating is especially important in almost everywhere food environments,” he says. Jeff Davis At Swansea University, UK. “The authors used an elegant way to identify these important cell groups.”