Wellness

Can You Actually Delay Menopause?

EWhere though it is a normal part of the child’s reproductive woman, the menopause can be the lightning rod for emotional reactions. Some women are pleased to end their periods, along with the risk of unplanned pregnancy. Others fear the possibility of hot flashes, night sweating, mood changes, and other unpleasant symptoms related to menopause.

Meanwhile, others are still worried about increasing health risks – due to conditions such as osteoporosis, heart disease and dementia – that can come with the loss of ovarian function and dramatic decrease in estrogen levels that occur after menopause. This is partly the reason that some cultural scientists and influencers believe that delaying menopause may be a key to longevity.

“Ovarian ages are faster than many other members, and they are often faster than the woman herself,” says Dr. Zev Williams, Director of the Fertility Center at the University of Colombia and head of the Department of Endocrine and Fertility at the University of Colombia’s Medical Center. “Today, where women have a longer life, the extension of the functional life of the ovary can have a meaningful effect on health and the quality of life in the long run.”

It is a controversial suggestion for various reasons. “The idea of ​​delaying menopause is meaningless, because we are not talking about fertility and women’s periods,” says neurologist Jennifer Jarison, co -director of the Women’s Health Aging Center at the Pak Institute to search for aging in Novato, California. Take advantage of giving women’s options to maintain ovarian endocrine function is to maintain the quality of a consistent life for several years. “

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In fact, some people (without evidence) believe that delaying menopause can extend the age of women and health. “There is no evidence that this is a youth fountain,” says Dr. Stephanie Fobion, medical director of the menopause and the director of the Mayo Clinic Center for Center. “At the end of the day, it will be very great if we can make the ovary not a time limit, but I don’t know how we can do that, and we do not know what the possible negative aspects are.”

However, the same idea prompted some scientists to investigate whether menopause can be delayed in healthy women, and how this can be done.

One of the most used methods in cancer patients highlights and freezes the ovary surgical parts, then re-implanting melted tissues after years to restore the ovarian function. in Ticket It was published in the number of 2024 from The American Journal of Gynecology and Childbirth, The researchers predicted that for most women under the age of 40, maintaining ovarian tissue and planting will lead to a great delay in menopause.

“It is currently logical for women who suffer from cancer treatment that will destroy ovarian tissue,” says Dr. Nannett Santoro, Professor and Head of Gynecology at the College of Medicine at the University of Colorado. “Most applications are for fertility and not to extend age when menopause by maintaining ovarian action.”

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With another approach, researchers were at the University of Colombia Investigation The use of Rapamycin immune drugs, which is usually used to prevent the refusal of organ transplantation, is used to delay ovarian aging. The goal here is not necessarily the extension of fertility, but rather slowing the rate that the ovaries era.

Initial studies in mice show that Rapamisin can reduce ovarian aging by 20 %. The researchers team is currently investigating whether these benefits are translated into women. And he promised these early developments, it is important to wait for the results from the continuous Vibrant Williams, who is involved in the study, says: To determine whether Rapamycin is safe and effective to delay ovarian aging in women, says Williams, who participates in the study.

In the opinion of Santoro (which does not participate in the study), “this will have its most urgent application to women who face early menopause. We know that menopause before the age of 45 has healthy consequences. So reaching everyone until the age of 45 years. [for menopause] It is likely to lead to a clear benefit for the health of the population. “

Meanwhile, some companies are working to develop new drugs that can slow ovarian aging. “The challenge facing any new medication is to show its effectiveness, ensure a favorable profile, and to address obstacles in cost and production,” says Williams. “The feature of reusing a drug like Rapamycin is that it has been widely used for decades, which means that its safety profile is firm and is available at a relatively low cost.”

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However, even if possible, more research must be done to determine whether it is already logical to extend the ovaries of the “normal” ovaries when menopause, which ranges from 45 to 55. “It is possible that there will be aspects and negative aspects. [who are] In danger, perhaps Reducing the risk of heart disease Reducing the risk of dementia. But this must be proven before applying it to the whole population. ”

On the other hand, potential comparison includes an increased risk of breast, uterine cancer and blood clotting events, says Santooro. This may happen because a woman will be exposed to estrogen for a longer period.

“There are also many women who will not do it You want to continue to have menstruation periods. “For example, women with fibroids, painful periods, uterine lining, menstrual headache, and severe menstrual syndrome” often find menopause to serve as a blessed comfort. “Aging – even from ovaries – sometimes has privileges.

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