Wellness

What do GLP-1 drugs really tell us about the brain’s reward system?

“I can’t believe how I no longer yearn for alcohol!” One person writes. Others declare: “Take the first shot … he hasn’t had a drink or a cigarette since then,” and “I love coffee, but I noticed that I cannot finish a cup anymore.”

All of these quotes were collected in a recent study led by David Arillauta at the University of Florence, Italy, from Redit to lose weight. Here, you will find many people who wander around the benefits of drugs such as Wegovy and OzemPIC. These treatments help people to reduce eating should not be surprising: this is exactly what it is intended to do, by simulating the hormone satiety (see “How do they work?”less).

This article is part of a special chain achieved in the GLP-1 mutation. Read more here.

Among the comments, you will repeatedly find reports of other unexpected behavioral changes. According to these calculations, when taking these medications, the desire to drink alcohol, smoke and even shopping is mandatory (but not sexual desire, although anecdotal reports on this topic elsewhere on the Internet are mixed). Such stories have become familiar in prescribing doctors.

If this anecdotal data can be supported through monitoring clinical trials, you may tell us a lot about how the brain processes expectation and reward – and can also suggest completely new ways to deal with addiction. By targeting the brain areas responsible for the remedies of food, the GLP-1 drugs may reduce the rewards that people get from other things, such as addictive substances. But what does the current evidence about these complex behavioral operations show?

First, we need to understand how the drug …

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