The evidence is escalating that the microbe is called Methanobrevibacter Smithii participates in colon and rectum cancer
Kateryna Kon/Science Photo Library/Alamy
It seems that the mysterious ancient microorganisms that are not bacteria or viruses play a role in the colon and rectum cancer. This supports the idea that such microbes, which were believed to be harmless, could already participate in human disease.
There are three areas of life. The first consists of one -cell bacteria. The second consists of living organisms known as the nucleus realities that are often multi -cell, including all animals and plants. These have larger cells packed with internal structures, including a nucleus stuffed with DNA.
Archaea is the third field. These are the one -cell living organisms that were originally believed to be bacteria because they lack a nucleus, but they were found to exchange some similarities with the male realities. In fact, it is now believed Perhaps the real nucleus was the bacteria that flooded freedom of living.
Although trillion bacteria and viruses that lie within our intestine have been linked to many cases – including cancer, diabetes, obesity and heart disease – the archaeological that lives there is usually not examined for such ties.
“Most scientists who work on human microbium ignore Archaea and completely filter these living organisms.” Roxy Hamadzadeh At Graz Medical University in Austria. However, large numbers of Archaea were seen along with circumstances, including Colon and rectal cancerand Parkinson’s disease And infections Gum and Urinary tract.
To better understand these associations, Hamdzada and their colleagues searched for any signatures of the intestine for diseases in 19 clinical studies covering more than 1,800 individuals.
They found that the links between Archaea and a group of medical conditions are common but variable. However, they discovered a fixed increase in Archaeon known as Methanobrevibacter Smithii In people with colon and rectal cancer. This organism plays a big role in digestion by consuming bacterial fermentation products, such as hydrogen, carbon dioxide, and methane release.
The team found, through modeling and cultivation of microbes, that M Smithti Interact with bacteria, including Pacteroides fragileand Escherichia coli and fusobacterium nucleatum.
These three types have been linked to colon and rectum before, but it was Relationship with F. nucleatum This looked more prominent. Exist M Smithtiand F. nucleatum It was produced much more than a compound known as SUCCINATE, which is the critical metabolism molecule. However, it is known in cancer Enhancing the invasion of the tumor and its ability to spread.
“It is the first mechanical guide to show the role of Archaea on human diseases and colon and rectal cancer specifically.”
This study supports linking the previous work M. Smithii With colon and rectal cancer, he says Gianmarco Piccinno At the University of Trento in Italy. But given that most of the evidence so far is only related, he says that more research is needed to determine any mechanisms to cause cancer and why people with colon and rectum cancer suffer from this microbe.
“While archaeological was recognized as ingredients for human microbium, its direct participation in the disease remained poorly understood,” he says. Sunny At Nianang Technology University in Singapore, which also has The links between Archaea and colon and rectum cancer were recently reported. “Although it is in a much smaller numbers of bacteria in the intestine, it is metabolicly active and often consumes hydrogen, produces methane and interacts with bacteria, as well as the host.”
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